Mkhuseli started his career in the oil industry with Shell, as a Retail Territory Manager and proceeded to be the Managing Director of Afric Oil, South Africa’s first black oil company.
As the founder of Calulo Investments, he is one of the authors of the South Africa’s first Black Economic Empowerment charters, the Liquid Fuels Charter.
He is the founding member of the SA’s World Petroleum Congress and Nepad Energy, having served on both committees. He serves in several boards both listed and unlisted and is a Governor of the board of Rhodes University.
He is an alumni of Rhodes University, Wits Business School and Harvard Business School in Boston United States of America, where he read legal studies, industrial sociology, advanced management skills and Executive Leadership and Entrepreneurialship.